The synthesis of o‐ and p‐[18F]fluorobenzyl bromides and their application to the prepatation of labeled neuroleptics

Kentaro Hatano, Tatsuo Ido, Ren Iwata

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    The syntheses of o‐ and p‐ [18F]fluorobenzyl bromides as labeled synthons were described. They were obtained from nitrobenzaldehyde via a three step synthesis that exhibited good yield. The preparation of [18F]fluororinated analog of a benzamide neuroleptic, cis‐N‐[(2RS, 3RS)‐1‐[18F]fluorobenzyl‐2‐methylpyrrolidin‐3‐yl] ‐5‐chloro‐2‐methoxy‐4‐methylaminobenzamide, via N‐benzylation with the synthons was also mentioned.

    Original languageEnglish
    Pages (from-to)373-380
    Number of pages8
    JournalJournal of Labelled Compounds and Radiopharmaceuticals
    Volume29
    Issue number4
    DOIs
    Publication statusPublished - 1991 Apr

    Keywords

    • D‐Dopamine Receptor
    • Positron Emission Tomography
    • [F]Arylfluoride

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Biochemistry
    • Radiology Nuclear Medicine and imaging
    • Drug Discovery
    • Spectroscopy
    • Organic Chemistry

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