Abstract
We have developed a practical synthetic route to constrained β-strand mimetic templates by regioselective 1,3-dipolar cycloaddition of azomethine imines with vinyl sulfone. A small library of β-strand mimetic templates was generated which include potent and selective inhibitors of serine proteases.
Original language | English |
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Pages (from-to) | 1305-1308 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 42 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2001 Feb 12 |
Externally published | Yes |
Keywords
- 1,3-Dipolar cycloaddition
- Peptidomimetics
- Serine protease inhibitor
- Vinyl sulfone
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry