The Survey in Clinical Practice of Sublingual Immunotherapy in Patients with Japanese Cedar Pollinosis using Self-written Questionnaire from First Season to Fourth Season

Yusuke Kusano, Nobuo Ohta, Atsushi Yuta, Yukiko Ogawa, Fumi Shoji, Toshiichi Awataguchi, Naohiro Suzuki, Toshihiko Chiba, Shiketsu Chin, Chikashi Kusakari, Kousei Takeda, Junichi Kanbayashi, Nobuyuki Shiga, Yusuke Otake, Yusuke Suzuki, Yoshihiro Shibahara, Seiichiro Nakabayashi, Naoki Inamura, Hiroshi Osafune, Kota WadaSeiji Kakehata, Yukio Katori, Yoshitaka Okamoto

Research output: Contribution to journalArticlepeer-review

Abstract

Four seasons have passed since sublingual immunotherapy was released in 2014 for patients with Japanese cedar pollinosis. However, it is often unclear how its treatment should be performed in clinical practice. We reported results of similar survey we conducted in 2016 and 2017. This time, we again investigated, after the end of pollen scattering period in 2018, the clinical usage level, subjective treatment effects, adverse effects, satisfaction level and sense of burden in treatment by using self-written questionnaire for 431 patients who began treatment from 2014 to 2017. The age distribution shows bimodal distribution in the 10s and 40s. The portion of patients who were aware of treatment effects tends to be higher after the second season than the first season, therefore it is suggested that it is preferable to continue for at least two seasons. The portion of patients who complained adverse reactions in the first season was 23.4% and it decreased to 5.6%, 5.0%, 1.2% in the second, third or fourth season respectively. If it can be continued for one season, it is unlikely that it will be a problem for the continuation of treatment after the second season. Some patients do not want to continue the treatment in the fourth season, and when to end treatment is needed to consider in the future.

Original languageEnglish
Pages (from-to)469-475
Number of pages7
JournalJournal of Otolaryngology of Japan
Volume123
Issue number6
DOIs
Publication statusPublished - 2020 Jun 20

Keywords

  • Japanese cedar pollinosis
  • Questionnaire survey
  • Sublingual immunotherapy

ASJC Scopus subject areas

  • Otorhinolaryngology

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