The sulfated polysaccharide porphyran reduces apolipoprotein B100 secretion and lipid synthesis in HepG2 cells

Nao Inoue, Naomi Yamano, Kotaro Sakata, Koji Nagao, Yoichiro Hama, Teruyoshi Yanagita

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

The physiological effect of porphyran, a sulfated polysaccharides from an edible red alga, was studied in human hepatoma HepG2 cells. Porphyran supplementation significantly decreased apolipoprotein B100 secretion, and the reduction was partly associated with suppression of cellular lipid synthesis in HepG2 cells. This is the first study to elucidate the mechanism of the hypolipidemic effect of porphyran.

Original languageEnglish
Pages (from-to)447-449
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume73
Issue number2
DOIs
Publication statusPublished - 2009

Keywords

  • Apolipoprotein B100
  • HepG2
  • Lipid synthesis
  • Porphyran

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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