The sulfated polysaccharide porphyran reduces apolipoprotein B100 secretion and lipid synthesis in HepG2 cells

Nao Inoue; Naomi Yamano; Kotaro Sakata; Koji Nagao; Yoichiro Hama; Teruyoshi Yanagita

doi:10.1271/bbb.80688

The sulfated polysaccharide porphyran reduces apolipoprotein B100 secretion and lipid synthesis in HepG2 cells

Nao Inoue, Naomi Yamano, Kotaro Sakata, Koji Nagao, Yoichiro Hama, Teruyoshi Yanagita

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

The physiological effect of porphyran, a sulfated polysaccharides from an edible red alga, was studied in human hepatoma HepG2 cells. Porphyran supplementation significantly decreased apolipoprotein B100 secretion, and the reduction was partly associated with suppression of cellular lipid synthesis in HepG2 cells. This is the first study to elucidate the mechanism of the hypolipidemic effect of porphyran.

Original language	English
Pages (from-to)	447-449
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	73
Issue number	2
DOIs	https://doi.org/10.1271/bbb.80688
Publication status	Published - 2009
Externally published	Yes

Keywords

Apolipoprotein B100
HepG2
Lipid synthesis
Porphyran

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.80688

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abstract = "The physiological effect of porphyran, a sulfated polysaccharides from an edible red alga, was studied in human hepatoma HepG2 cells. Porphyran supplementation significantly decreased apolipoprotein B100 secretion, and the reduction was partly associated with suppression of cellular lipid synthesis in HepG2 cells. This is the first study to elucidate the mechanism of the hypolipidemic effect of porphyran.",

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author = "Nao Inoue and Naomi Yamano and Kotaro Sakata and Koji Nagao and Yoichiro Hama and Teruyoshi Yanagita",

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journal = "Bioscience, Biotechnology and Biochemistry",

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AU - Inoue, Nao

AU - Yamano, Naomi

AU - Sakata, Kotaro

AU - Nagao, Koji

AU - Hama, Yoichiro

AU - Yanagita, Teruyoshi

PY - 2009

Y1 - 2009

N2 - The physiological effect of porphyran, a sulfated polysaccharides from an edible red alga, was studied in human hepatoma HepG2 cells. Porphyran supplementation significantly decreased apolipoprotein B100 secretion, and the reduction was partly associated with suppression of cellular lipid synthesis in HepG2 cells. This is the first study to elucidate the mechanism of the hypolipidemic effect of porphyran.

AB - The physiological effect of porphyran, a sulfated polysaccharides from an edible red alga, was studied in human hepatoma HepG2 cells. Porphyran supplementation significantly decreased apolipoprotein B100 secretion, and the reduction was partly associated with suppression of cellular lipid synthesis in HepG2 cells. This is the first study to elucidate the mechanism of the hypolipidemic effect of porphyran.

KW - Apolipoprotein B100

KW - HepG2

KW - Lipid synthesis

KW - Porphyran

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JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

SN - 0916-8451

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The sulfated polysaccharide porphyran reduces apolipoprotein B100 secretion and lipid synthesis in HepG2 cells

Abstract

Keywords

ASJC Scopus subject areas

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