The sulfated polysaccharide porphyran reduces apolipoprotein B100 secretion and lipid synthesis in HepG2 cells

Nao Inoue; Naomi Yamano; Kotaro Sakata; Koji Nagao; Yoichiro Hama; Teruyoshi Yanagita

doi:10.1271/bbb.80688

The sulfated polysaccharide porphyran reduces apolipoprotein B100 secretion and lipid synthesis in HepG2 cells

Nao Inoue, Naomi Yamano, Kotaro Sakata, Koji Nagao, Yoichiro Hama, Teruyoshi Yanagita

AGR - Bioscience and Biotechnology for Future Bioindustries

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

The physiological effect of porphyran, a sulfated polysaccharides from an edible red alga, was studied in human hepatoma HepG2 cells. Porphyran supplementation significantly decreased apolipoprotein B100 secretion, and the reduction was partly associated with suppression of cellular lipid synthesis in HepG2 cells. This is the first study to elucidate the mechanism of the hypolipidemic effect of porphyran.

Original language	English
Pages (from-to)	447-449
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	73
Issue number	2
DOIs	https://doi.org/10.1271/bbb.80688
Publication status	Published - 2009

Keywords

Apolipoprotein B100
HepG2
Lipid synthesis
Porphyran

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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AU - Yamano, Naomi

AU - Sakata, Kotaro

AU - Nagao, Koji

AU - Hama, Yoichiro

AU - Yanagita, Teruyoshi

PY - 2009

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