TY - JOUR
T1 - The study on β-lactamase of cefotaxime resistance escherichia coli
AU - Matsuo, H.
AU - Ma, L.
AU - Ishii, Y.
AU - Kaku, M.
AU - Yamaguchi, K.
N1 - Copyright:
Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.
PY - 1997
Y1 - 1997
N2 - Five strains of cefotaxime-resistant (≤ 128 μg/ml) Escherichia coli were isolated from hospitals in Nagasaki Prefecture. These E. coli strains showed resistance against 3rd generation cephems and aztreonam (64μg/ml), but these strains were sensitive against imipenem. The antibiotic activity of piperacillin alone to these E. coli strains were > 128 μg/ml, in contrast, MIC values of piperacillin combined with tazobactam as a β-lactamase inhibitor were 4-32 μg/ml. These resistance were carried by a conjugative plasmid encoding for β-lactamases. These results suggested that 5 strains of E. coli were shown resistance against β-lactams by producing class A β- lactamase.
AB - Five strains of cefotaxime-resistant (≤ 128 μg/ml) Escherichia coli were isolated from hospitals in Nagasaki Prefecture. These E. coli strains showed resistance against 3rd generation cephems and aztreonam (64μg/ml), but these strains were sensitive against imipenem. The antibiotic activity of piperacillin alone to these E. coli strains were > 128 μg/ml, in contrast, MIC values of piperacillin combined with tazobactam as a β-lactamase inhibitor were 4-32 μg/ml. These resistance were carried by a conjugative plasmid encoding for β-lactamases. These results suggested that 5 strains of E. coli were shown resistance against β-lactams by producing class A β- lactamase.
KW - Cefotaxamine-hydrolizing β-lactamase
KW - Cefoxamine-resistant Escherichia coli
KW - Extended-spectrum ̄- lactamase
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M3 - Article
AN - SCOPUS:0030864139
VL - 18
SP - 221
EP - 225
JO - Therapeutic Research
JF - Therapeutic Research
SN - 0289-8020
IS - 7
ER -