The strong relation between post-hemodialysis blood methylglyoxal levels and post-hemodialysis blood glucose concentration rise

Miho Senda, Susumu Ogawa, Kazuhiro Nako, Masashi Okamura, Takuya Sakamoto, Sadayoshi Ito

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Background: Hemodialysis is known to decrease blood glucose concentration (BGC), insulin, and methylglyoxal levels. However, the effects of decreases in these factors on the increase in post-hemodialysis BGC remain unknown. This study identifies the effects of hemodialysis-induced changes in concentrations of these elements on post-hemodialysis BGC. Methods: Study subjects included seventeen insulin-treated diabetes patients receiving hemodialysis. The fluctuations in BGC on hemodialysis-treatment days and non-hemodialysis-treatment days were evaluated using a continuous glucose monitoring system. BGC was evaluated before breakfast, before starting hemodialysis, at the end of hemodialysis, 1 h post-hemodialysis (lunch), and 6 h post-hemodialysis (dinner). BGC, insulin, and methylglyoxal levels were measured at the start and end of hemodialysis. This study also evaluated the changes in the concentrations of glucose and insulin in the arterial line and the venous line during hemodialysis. Results: Hemodialysis decreases BGC, insulin, and methylglyoxal levels. Concentrations of glucose and insulin in the arterial line gradually decreased during dialysis, while concentrations in the venous line approached their original concentrations in the dialysis solution. BGC rose sharply after eating lunch 1 h post-hemodialysis. The blood glucose, insulin, and methylglyoxal concentrations at the end of hemodialysis were associated with the M values and the mean amplitude of glycemic excursion values between before lunch and dinner. In particular, methylglyoxal concentration at the end of hemodialysis was strongly related to the post-hemodialysis increase in BGC. Conclusion: Hemodialysis-induced decreases in methylglyoxal concentrations and methylglyoxal concentration at the end of hemodialysis influence post-hemodialysis fluctuations in BGC.

Original languageEnglish
Pages (from-to)527-533
Number of pages7
JournalClinical and experimental nephrology
Volume19
Issue number3
DOIs
Publication statusPublished - 2015 Jun 17

Keywords

  • Continuous glucose monitoring system
  • Methylglyoxal
  • Post-hemodialysis blood glucose fluctuations

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'The strong relation between post-hemodialysis blood methylglyoxal levels and post-hemodialysis blood glucose concentration rise'. Together they form a unique fingerprint.

Cite this