The stimulatory effect of PDGF on vascular smooth muscle cell migration is mediated by the induction of endogenous basic FGF

Yasufumi Sato, Ryoji Hamanaka, Junko Ono, Michihiko Kuwano, Daniel B. Rifkin, Ryosaburo Takaki

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

The migration of arterial smooth muscle cells from the media to the intima is a crucial event for the development of the atherosclerotic lesion, and platelet derived growth factor (PDGF) is thought to play an important role in this process. Here we report that the spontaneous migration of bovine smooth muscle (BSM) cells is dependent on endogenously produced basic fibroblast growth factor (bFGF). PDGF stimulates the migration of BSM cells and its effect is abolished by affinity purified anti-bFGF antibody. PDGF induces bFGF mRNA in BSM cells. These results indicate that the effect of PDGF on the migration of BSM cells may be mediated by the induction of endogenous bFGF.

Original languageEnglish
Pages (from-to)1260-1266
Number of pages7
JournalBiochemical and biophysical research communications
Volume174
Issue number3
DOIs
Publication statusPublished - 1991 Feb 14
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'The stimulatory effect of PDGF on vascular smooth muscle cell migration is mediated by the induction of endogenous basic FGF'. Together they form a unique fingerprint.

Cite this