The sphingosine 1-phosphate receptor modulator FTY720 prevents iodide-induced autoimmune thyroiditis in non-obese diabetic mice

Kazuki Morohoshi, Michiko Osone, Katsumi Yoshida, Yoshinori Nakagawa, Saeko Hoshikawa, Hiroshi Ozaki, Yurie Takahashi, Sadayoshi Ito, Kouki Mori

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6 Citations (Scopus)

Abstract

FTY720 is an immunomodulator that alters migration and homing of lymphocytes via sphingosine 1-phosphate receptors. This compound has been shown to be effective in suppressing autoimmune diseases in experimental and clinical settings. In the present study, we tested whether FTY720 prevented autoimmune thyroiditis in iodide-treated non-obese diabetic (NOD) mice, a model of Hashimoto's thyroiditis (HT) in humans. Mice were given 0.05% iodide water for 8 weeks, and this treatment effectively induced thyroiditis. Iodide-treated mice were injected intraperitoneally with either saline or FTY720 during the iodide treatment. FTY720 clearly suppressed the development of thyroiditis and reduced serum anti-thyroglobulin antibody levels. The number of circulating lymphocytes and spleen cells including CD4 + T cells, CD8 + T cells, and CD4 +Foxp3 + T cells was decreased in FTY720-treated mice. Our results indicate that FTY720 has immunomodulatory effects on iodide-induced autoimmune thyroiditis in NOD mice and may be a potential candidate for use in the prevention of HT.

Original languageEnglish
Pages (from-to)490-495
Number of pages6
JournalAutoimmunity
Volume44
Issue number6
DOIs
Publication statusPublished - 2011 Sep

Keywords

  • FTY720
  • Hashimoto's thyroiditis
  • Lymphocyte homing
  • Non-obese diabetic mouse
  • Sphingosine 1-phosphate receptor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Morohoshi, K., Osone, M., Yoshida, K., Nakagawa, Y., Hoshikawa, S., Ozaki, H., Takahashi, Y., Ito, S., & Mori, K. (2011). The sphingosine 1-phosphate receptor modulator FTY720 prevents iodide-induced autoimmune thyroiditis in non-obese diabetic mice. Autoimmunity, 44(6), 490-495. https://doi.org/10.3109/08916934.2011.558145