The somatic mutation frequency of the transforming growth factor β receptor type II gene varies widely among different cancers with microsatellite instability

Tadayoshi Abe, Hong Ouyang, Takashi Migita, Yo Kato, Mitsuhiro Kimura, Kenichi Shiiba, Makoto Sunamura, Seiki Matsuno, Akira Horii

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Disruption of the DNA mismatch repair system, characterized by microsatellite instability (MSI), plays an important role in the course of human carcinogenesis. Frequent somatic mutations in a polyadenine (poly(A)) tract and two GT repeats within the coding region of the transforming growth factor β (TGFβ) receptor II (RII) gene were reported in colorectal cancers with MSI. We examined mutations of RII in cancers of various organs with MSI and found deletions at the poly(A) tract in eight of nine (89%) gastric cancers and four of five (80%) colorectal cancers. In contrast, no mutations were found in cancers of the pancreas, endometrium, or lungs. These results suggest that TGFβ-mediated growth control plays a very important role in the stomach and colorectum.

Original languageEnglish
Pages (from-to)474-477
Number of pages4
JournalEuropean Journal of Surgical Oncology
Volume22
Issue number5
DOIs
Publication statusPublished - 1996 Jan 1

Keywords

  • Colorectal cancer
  • Gastric cancer
  • MSI
  • RII

ASJC Scopus subject areas

  • Surgery
  • Oncology

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