The solid-phase parallel synthesis of β-strand mimetic templates via 1,3-dipolar cycloaddition with resin-bound vinylsulfone

Nobuhiro Fuchi, Takayuki Doi, Bolong Cao, Michael Kahn, Takashi Takahashi

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

A facile synthesis of a conformationally restricted β-strand mimetic library is described. Regioselective 1,3-dipolar cycloaddition with a resin-bound vinylsulfone provides a structurally diverse β-strand templated library. This library includes potent and selective inhibitors of serine proteases.

Original languageEnglish
Pages (from-to)285-289
Number of pages5
JournalSynlett
Issue number2
DOIs
Publication statusPublished - 2002 Jan 1
Externally publishedYes

Keywords

  • 1,3-dipolar cycloadditions
  • Combinatorial chemistry
  • Serine-protease inhibitor
  • Solid-phase synthesis
  • Vinylsulfones

ASJC Scopus subject areas

  • Organic Chemistry

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