The significance of oxidized DJ-1 protein (oxDJ-1) as a biomarker for parkinson's disease

Ikuko Ogawa, Yoshiro Saito, Kazumasa Saigoh, Yoshie Hosoi, Yoshiyuki Mitsui, Noriko Noguchi, Susumu Kusunoki

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The search for biomarkers of Parkinson's disease (PD) typically focuses on cerebrospinal fluid components, with very few reports on simple biomarkers identifiable by blood analysis. In this report, we determined the level of oxidized DJ-1 protein (oxDJ-1) in red blood cells by ELISA and examined the association with MIBG myocardial scintigraphy. Levels of oxDJ-1 were higher in unmedicated patients with PD (142.2 ± 21.8 ng oxDJ-1/mg protein; n = 13) compared to the L-DOPA-treated group (85.6 ± 10.1 ng oxDJ-1/mg protein; n = 10) and controls (56.0 ± 6.2 ng oxDJ-1/mg protein; n = 17), thereby showing significant intergroup differences. Intervention with L-DOPA showed a tendency to decrease oxDJ-1 levels in patients. The diagnostic sensitivity of oxDJ-1 measurement was 87% and that of simultaneously conducted MIBG scintigraphy was 89%; this showed that the diagnostic sensitivity was comparable. Our results showed that measurement of oxDJ-1 levels in red blood cells can be useful and oxDJ-1 can be used as a biomarker for the early diagnosis of PD.

Original languageEnglish
Pages (from-to)471-477
Number of pages7
JournalBrain and Nerve
Volume66
Issue number4
Publication statusPublished - 2014 Apr
Externally publishedYes

Keywords

  • Biomarker
  • Gene
  • MIBG scintigraphy
  • Oxidized DJ-1(oxDJ-1)
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology

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