The selective binding of HMG1 to the cruciform DNA structure and the subsequent resumption of transcription.

S. Waga, H. Shirakawa, S. Mizuno, M. Yoshida

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    The binding of DNA binding protein HMG1 to palindromic sequences that can form the cruciform structure in supercoiled DNA and the subsequent effects on the transcription of the sequence were examined. The results show that the cruciform structure formed under negative supercoiling is a block to transcription and that HMG1, which bound selectively to single-stranded region within the cruciform, can remove the block by altering DNA conformation to allow the stalled RNA polymerase at the block to resume transcription.

    Original languageEnglish
    Pages (from-to)81-82
    Number of pages2
    JournalNucleic acids symposium series
    Issue number22
    Publication statusPublished - 1990

    ASJC Scopus subject areas

    • Medicine(all)

    Fingerprint

    Dive into the research topics of 'The selective binding of HMG1 to the cruciform DNA structure and the subsequent resumption of transcription.'. Together they form a unique fingerprint.

    Cite this