The second progress report on the Hypertension Objective treatment based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study

Shin Saito, Kei Asayama, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Taku Obara, Junichiro Hashimoto, Kazuhito Totsune, Yukio Miura, Yutaka Imai

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: The Hypertension Objective treatment based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study is a large-scale intervention trial to determine both optimal target blood pressure (BP) on the basis of self-measured BP at home, and optimal initial antihypertensive medication. Objective: To investigate the quality of randomization at the end of March 2003, and BP-controlled conditions during initial 6 months. Methods: We evaluated the number of patients randomized by the end of March 2003, and BP changes during the initial 6 months based on intention-to-treat analysis. Results: By the end of March 2003, a total of 1086 patients (12% of a planned randomization of 9000 patients) had been randomized. Among 653 patients who had been followed for ≥ 6 months after randomization, mean systolic/diastolic BPs at randomization in the calcium antagonist, angiotensin-converting enzyme and angiotensin II receptor blocker groups were 149/89, 150/89 and 149/88 mmHg, respectively. Blood pressures were reduced after 3 months (137/83, 139/82 and 136/82 mmHg, respectively), and further reduced after 6 months (134/81, 135/80 and 133/80 mmHg, respectively), with no significant differences identified between groups. In moreand less-intensive BP-lowering groups, mean systolic/ diastolic BPs at randomization were 149/88 and 150/89 mmHg, respectively. Although BPs were reduced after treatment for 3 months (137/83 and 137/82 mmHg, respectively) and 6 months (134/80 and 135/80 mmHg, respectively) in each target group, significant differences were still not observed between groups. Conclusions: Good quality of randomization was observed at the end of March 2003, but rate of achievement for target BPs was insufficient.

Original languageEnglish
Pages (from-to)243-247
Number of pages5
JournalBlood pressure monitoring
Volume9
Issue number5
DOIs
Publication statusPublished - 2004 Oct

Keywords

  • Blood pressure measurement at home
  • Hypertension
  • Internet
  • Prospective randomized open-label blinded-endpoint (PROBE)
  • Randomized controlled trial (RCT)

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Assessment and Diagnosis
  • Advanced and Specialised Nursing

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