The role of volume-weighted mean nuclear volume in predicting tumour biology and clinical behaviour in patients with prostate cancer undergoing watchful waiting

Y. Arai, S. Egawa, S. Kuwao, K. Ogura, S. Baba

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Objective: To investigate whether the volume-weighted mean nuclear volume (MNV, the only means by which unbiased estimates of three-dimensional variables can be obtained from a two-dimensional section by stereological methods) at diagnosis correlates with tumour biology and clinical behaviour in patients with prostate cancer treated by watchful waiting. Patients and methods: In a prognostic study, 64 patients with clinically localized prostate cancer were followed prospectively with initial expectant management. The median (mean, range) follow-up was 22 (27, 6.0-68) months. The prostate specific antigen (PSA) doubling time (PSADT) was calculated by linear regression. The MNV was estimated using biopsy specimens, based on a stereological method, and compared with PSADT and traditional clinicopathological variables. Results: PSADT was significantly associated with MNV, but not with other clinicopathological variables. The PSA 'rapid-riser' subset (PSADT < median value) had significantly larger MNVs than did the PSA 'slow-riser' (PSADT ≥ median value) and PSA-stable subsets (P = 0.0017 and 0.004, respectively). On multivariate analysis using a stepwise Cox proportional hazards regression, only MNV remained independently significant as a predictor of clinical progression among the clinicopathological variables (P < 0.001). Conclusions: These findings suggest that cancer cell nuclear volume is significantly associated with tumour biology and behaviour in patients with prostate cancer. Although further study with a larger patient population is needed to confirm the findings, estimates of MNV may be an important prognostic indicator in men treated with watchful waiting.

Original languageEnglish
Pages (from-to)909-914
Number of pages6
JournalBJU International
Volume88
Issue number9
DOIs
Publication statusPublished - 2001

Keywords

  • Mean nuclear volume
  • PSA doubling time
  • Prostate cancer
  • Watchful waiting

ASJC Scopus subject areas

  • Urology

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