The role of the transcription factor pax6 in brain development and evolution: Evidence and hypothesis

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

During mammalian corticogenesis, the dorsal telencephalon is patterned through secreted molecules an transcription factors. Expression of the transcription factor Pax6 demarcates the dorsal telencephalon, thereby patterning the future cortical primordium. Pax6 is also crucial in neurogenesis in the developing cortex through its role in balancing proliferation and differentiation of neural progenitor cells (NPCs). In this chapter, we address the role of Pax6 and its downstream molecules in cortical development and evolution. We also note the possible involvement of Pax6 in the onset of neurodevelopmental diseases.

Original languageEnglish
Title of host publicationCortical Development
Subtitle of host publicationNeural Diversity and Neocortical Organization
PublisherSpringer Japan
Pages43-62
Number of pages20
ISBN (Electronic)9784431544968
ISBN (Print)9784431544951
DOIs
Publication statusPublished - 2013 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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