The role of sex hormones in the kinetics of chondrocytes in the growth plate. A study in the rabbit

T. Irie, T. Aizawa, S. Kokubun

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Sex hormones play important roles in the regulation of the proliferation, maturation and death of chondrocytes in the epiphyseal growth plate. We have investigated the effects of male castration on the cell kinetics of chondrocytes as defined by the numbers of proliferating and dying cells. The growth plates of normal rabbits and animals castrated at eight weeks of age were obtained at 10, 15, 20 and 25 weeks of age. Our study suggested that castration led to an increase in apoptosis and a decrease in the proliferation of chondrocytes in the growth plate. In addition, the number of chondrocytes in the castrated rabbits was less than that of normal animals of the same age.

Original languageEnglish
Pages (from-to)1278-1284
Number of pages7
JournalJournal of Bone and Joint Surgery - Series B
Volume87
Issue number9
DOIs
Publication statusPublished - 2005 Sep

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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