The Role of hnRPUL1 Involved in DNA Damage Response Is Related to PARP1

Zehui Hong, Jie Jiang, Jiaolong Ma, Shikui Dai, Ting Xu, Hui Li, Akira Yasui

    Research output: Contribution to journalArticlepeer-review

    24 Citations (Scopus)

    Abstract

    Heterogeneous nuclear ribonucleoprotein U-like 1 (hnRPUL1) -also known as adenovirus early region 1B-associated proteins 5 (E1B-AP5) - plays a role in RNA metabolism. Recently, hnRPUL1 has also been shown to be involved in DNA damage response, but the function of hnRPUL1 in response to DNA damage remains unclear. Here, we have demonstrated that hnRPUL1 is associated with PARP1 and recruited to DNA double-strand breaks (DSBs) sites in a PARP1-mediated poly (ADP-ribosyl) ation dependent manner. In turn, hnRPUL1 knockdown enhances the recruitment of PARP1 to DSBs sites. Specifically, we showed that hnRPUL1 is also implicated in the transcriptional regulation of PARP1 gene. Thus, we propose hnRPUL1 as a new component related to PARP1 in DNA damage response and repair.

    Original languageEnglish
    Article numbere60208
    JournalPloS one
    Volume8
    Issue number4
    DOIs
    Publication statusPublished - 2013 Apr 5

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • Agricultural and Biological Sciences(all)
    • General

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