The role of hemolymph coagulation in innate immunity

Tatsushi Muta, Sadaaki Iwanaga

Research output: Contribution to journalArticlepeer-review

227 Citations (Scopus)


Invertebrate animals, which lack adaptive immune systems, have developed defense systems that respond to common antigens on the surface of potential pathogens. Hemolymph coagulation is one such defense system in innate immunity. The discovery of lipopolysaccharide-sensitive and (1 → 3)-β-D-glucan-sensitive serine protease zymogens in horseshoe crab (limulus) hemocytes, both of which trigger the coagulation cascade, has exemplified how the animals detect and respond to foreign materials.

Original languageEnglish
Pages (from-to)41-47
Number of pages7
JournalCurrent Opinion in Immunology
Issue number1
Publication statusPublished - 1996 Feb
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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