The role of estrogen-metabolizing enzymes and estrogen receptors in human epidermis

Takayoshi Inoue, Yasuhiro Miki, Keiko Abe, Masahito Hatori, Masami Hosaka, Yoshiyuki Kariya, Shingo Kakuo, Tsutomu Fujimura, Akira Hachiya, Setsuya Aiba, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Local estrogen metabolism and its sensitivities in the skin have been also suggested to contribute to skin homeostasis in addition to age- and/or gender-dependent circulating estrogen, even though their local mechanisms have been largely unknown. To characterize their potential correlations, age- and gender-dependencies were evaluated focusing on 5 pivotal estrogen-metabolizing enzymes including aromatase, estrogen sulfotransferase, steroid sulfatase, and 17β-hydroxysteroid dehydrogenases and estrogen receptors (ERα and ERβ) using immunohistochemistry of 100 human skin specimens. When their epidermal expression levels were compared among 7 age groups, ranging from the teens to the seventies, the highest expression in the teens group and the lowest expression in the seventies group were found in the expression of aromatase and ERβ, respectively, while no significant differences between the male and the female groups were found in the immunoreactivities of our interested proteins. Our results suggest that age-related differences in aromatase and ERβ expressions impact epidermal homeostasis.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalMolecular and Cellular Endocrinology
Issue number1-2
Publication statusPublished - 2011 Sep 15


  • Age
  • Aromatase
  • Epidermis
  • Estrogen receptors
  • Gender
  • Skin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology


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