The role of endogenous glucocorticoids in rat experimental models of acute pancreatitis

Reishi Abe, Tooru Shimosegawa, Kenji Kimura, Takashi Abe, Junya Kashimura, Masaru Koizumi, Takayoshi Toyota

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

Background & Aims: Cytokines activate the hypothalamic-pituitary-adrenal axis and suppress inflammation by stimulating glucocorticoid secretion. The state of adrenocortical function during acute pancreatitis and its role in this disease were determined. Methods: Cerulein-induced pancreatitis or closed duodenal loop pancreatitis was produced in rats that had undergone adrenalectomy or sham adrenalectomy, and the serum corticosterone and interleukin 8 levels and the intensity of the pancreatitis were examined. Results: Serum corticosterone levels were significantly higher than basal levels in both models of experimental pancreatitis. In both models, adrenalectomy increased serum amylase and pancreatic edema and produced more severe inflammation. Adrenalectomy significantly increased mortality in animals with closed duodenal loop pancreatitis. Exogenous hydrocortisone administered to adrenalectomized animals suppressed the elevation of serum interleukin 8 levels and decreased both the severity of pancreatitis and mortality. Conclusions: These results suggest that the adrenocortical function is stimulated during acute pancreatitis and that the secretion of endogenous glucocorticoids may play an important role in mitigating the progress of this disease, probably by inhibiting cytokine production.

Original languageEnglish
Pages (from-to)933-943
Number of pages11
JournalGastroenterology
Volume109
Issue number3
DOIs
Publication statusPublished - 1995 Sep

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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