The role of BK(Ca) channels in the nitric oxide-mediated regulation of adrenal catecholamine secretion

Takahiro Nagayama, Makoto Yoshida, Mizue Suzuki-Kusaba, Hiroaki Hisa, Tomohiko Kimura, Susumu Satoh

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We examined whether high conductance Ca2+-activated K+ (BK(Ca)) channels are involved in the modulatory action of nitric oxide (NO) on the secretion of adrenal catecholamines in response to splanchnic nerve stimulation and acetylcholine in anesthetized dogs. The NO donor 3-(2-hydroxy-1-methyl-2-nitrosohydrazino)-N-methyl-1-propanamine (NOC 7), the BK(Ca) channel blocker charybdotoxin and acetylcholine were administered intraarterially (i.a.) into the adrenal gland. NOC 7 infusion (2 μg min-1) inhibited increases in catecholamine output induced by splanchnic nerve stimulation (1-3 Hz) and acetylcholine (0.75-3 μg). Charybdotoxin infusion (100 ng min-1) did not affect increases in catecholamine output induced by splanchnic nerve stimulation and acetylcholine. Charybdotoxin blocked the NOC 7-induced inhibition of increases in catecholamine output induced by splanchnic nerve stimulation but not by acetylcholine. These results suggest that NO may inhibit the secretion of adrenal catecholamines induced by splanchnic nerve stimulation through activation of BK(Ca) channels. Copyright (C) 1998 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)169-176
Number of pages8
JournalEuropean Journal of Pharmacology
Volume353
Issue number2-3
DOIs
Publication statusPublished - 1998 Jul 24

Keywords

  • Adrenal
  • Catecholamine
  • Charybdotoxin
  • K channel, BK(Ca)
  • NOC 7 (3-(2-hydroxy-1-methyl-2-nitrosohydrazino)-N-methyl-1-propanamine)
  • Nitric oxide (NO)
  • Splanchnic nerve stimulation

ASJC Scopus subject areas

  • Pharmacology

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