The role of androgen under normal and pathological conditions in sebaceous glands: The possibility of target therapy

Abdullah Azmahani; Yasuhiro Nakamura; Keely M. McNamara; Hironobu Sasano

doi:10.2174/1874467208666150710120217

The role of androgen under normal and pathological conditions in sebaceous glands: The possibility of target therapy

Abdullah Azmahani, Yasuhiro Nakamura, Keely M. McNamara, Hironobu Sasano

MED - Medical Sciences

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

Abstract

The androgen receptor plays a pivotal role in the sebaceous glands. Its primary function is to stimulate cell proliferation and differentiation in the sebaceous and its associate with acne. Previous studies have demonstrated expression of AR and steroidogenic enzymes in normal sebaceous glands and in all sebaceous disorders present evidence that androgen receptor may be a sensitive marker of sebaceous differentiation. It has been previously suggested that AR and steroidogenic enzymes immunohistochemistry may be useful particularly in identifying poorly sebaceous carcinoma. This review will provide an overview of the AR functions in the sebaceous glands and discussion of the therapeutic targets in acne and carcinoma.

Original language	English
Pages (from-to)	311-319
Number of pages	9
Journal	Current Molecular Pharmacology
Volume	9
Issue number	4
DOIs	https://doi.org/10.2174/1874467208666150710120217
Publication status	Published - 2016 Nov 1

Keywords

Androgen receptor (AR)
Cell proliferation
Sebaceous gland
Sebocytes
Target therapy

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Drug Discovery

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10.2174/1874467208666150710120217

Cite this

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abstract = "The androgen receptor plays a pivotal role in the sebaceous glands. Its primary function is to stimulate cell proliferation and differentiation in the sebaceous and its associate with acne. Previous studies have demonstrated expression of AR and steroidogenic enzymes in normal sebaceous glands and in all sebaceous disorders present evidence that androgen receptor may be a sensitive marker of sebaceous differentiation. It has been previously suggested that AR and steroidogenic enzymes immunohistochemistry may be useful particularly in identifying poorly sebaceous carcinoma. This review will provide an overview of the AR functions in the sebaceous glands and discussion of the therapeutic targets in acne and carcinoma.",

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AU - Azmahani, Abdullah

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AU - Sasano, Hironobu

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N2 - The androgen receptor plays a pivotal role in the sebaceous glands. Its primary function is to stimulate cell proliferation and differentiation in the sebaceous and its associate with acne. Previous studies have demonstrated expression of AR and steroidogenic enzymes in normal sebaceous glands and in all sebaceous disorders present evidence that androgen receptor may be a sensitive marker of sebaceous differentiation. It has been previously suggested that AR and steroidogenic enzymes immunohistochemistry may be useful particularly in identifying poorly sebaceous carcinoma. This review will provide an overview of the AR functions in the sebaceous glands and discussion of the therapeutic targets in acne and carcinoma.

AB - The androgen receptor plays a pivotal role in the sebaceous glands. Its primary function is to stimulate cell proliferation and differentiation in the sebaceous and its associate with acne. Previous studies have demonstrated expression of AR and steroidogenic enzymes in normal sebaceous glands and in all sebaceous disorders present evidence that androgen receptor may be a sensitive marker of sebaceous differentiation. It has been previously suggested that AR and steroidogenic enzymes immunohistochemistry may be useful particularly in identifying poorly sebaceous carcinoma. This review will provide an overview of the AR functions in the sebaceous glands and discussion of the therapeutic targets in acne and carcinoma.

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The role of androgen under normal and pathological conditions in sebaceous glands: The possibility of target therapy

Abstract

Keywords

ASJC Scopus subject areas

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