The role of 17βHSDs in breast tissue and breast cancers

Keely May Mcnamara; Hironobu Sasano

doi:10.1016/j.mce.2018.10.019

The role of 17βHSDs in breast tissue and breast cancers

Keely May Mcnamara, Hironobu Sasano

MED - Medical Sciences

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

The family of seventeen beta hydroxysteroid dehydrogenase enzymes has a long and diverse history in breast and breast cancer research. Given the known dependence of the breast on steroid signalling and intracrine steroid metabolism these enzymes are considered to be essential local fine tuners of overall steroid balance in the tissue. This review will cover the current state of knowledge regarding the expression, clinical effect and biological regulation of enzymes in both cancerous and normal states. In addition we will also cover the current state of knowledge regarding 17βHSD actions in the often neglected adipose and stromal components of tumours.

Original language	English
Pages (from-to)	32-44
Number of pages	13
Journal	Molecular and Cellular Endocrinology
Volume	489
DOIs	https://doi.org/10.1016/j.mce.2018.10.019
Publication status	Published - 2019 Jun 1

Keywords

17βHSD
AKR1C3
Breast
Breast cancer

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mce.2018.10.019

Cite this

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title = "The role of 17βHSDs in breast tissue and breast cancers",

abstract = "The family of seventeen beta hydroxysteroid dehydrogenase enzymes has a long and diverse history in breast and breast cancer research. Given the known dependence of the breast on steroid signalling and intracrine steroid metabolism these enzymes are considered to be essential local fine tuners of overall steroid balance in the tissue. This review will cover the current state of knowledge regarding the expression, clinical effect and biological regulation of enzymes in both cancerous and normal states. In addition we will also cover the current state of knowledge regarding 17βHSD actions in the often neglected adipose and stromal components of tumours.",

keywords = "17βHSD, AKR1C3, Breast, Breast cancer",

author = "Mcnamara, {Keely May} and Hironobu Sasano",

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doi = "10.1016/j.mce.2018.10.019",

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AU - Mcnamara, Keely May

AU - Sasano, Hironobu

PY - 2019/6/1

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N2 - The family of seventeen beta hydroxysteroid dehydrogenase enzymes has a long and diverse history in breast and breast cancer research. Given the known dependence of the breast on steroid signalling and intracrine steroid metabolism these enzymes are considered to be essential local fine tuners of overall steroid balance in the tissue. This review will cover the current state of knowledge regarding the expression, clinical effect and biological regulation of enzymes in both cancerous and normal states. In addition we will also cover the current state of knowledge regarding 17βHSD actions in the often neglected adipose and stromal components of tumours.

AB - The family of seventeen beta hydroxysteroid dehydrogenase enzymes has a long and diverse history in breast and breast cancer research. Given the known dependence of the breast on steroid signalling and intracrine steroid metabolism these enzymes are considered to be essential local fine tuners of overall steroid balance in the tissue. This review will cover the current state of knowledge regarding the expression, clinical effect and biological regulation of enzymes in both cancerous and normal states. In addition we will also cover the current state of knowledge regarding 17βHSD actions in the often neglected adipose and stromal components of tumours.

KW - 17βHSD

KW - AKR1C3

KW - Breast

KW - Breast cancer

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DO - 10.1016/j.mce.2018.10.019

M3 - Review article

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AN - SCOPUS:85056541532

SN - 0303-7207

VL - 489

SP - 32

EP - 44

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

ER -

The role of 17βHSDs in breast tissue and breast cancers

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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