The ribosome collision sensor Hel2 functions as preventive quality control in the secretory pathway

Research output: Contribution to journalArticlepeer-review

Abstract

Matsuo and Inada utilize selective ribosome profiling to survey endogenous substrates for Hel2 and find that Hel2 preferentially binds to pre-engaged secretory RNCs lacking SRP recognition. They also show that Hel2-mediated quality control contributes to alleviation of mistargeting of secretory proteins into mitochondria caused by loss of the SRP.

Original languageEnglish
Article number108877
JournalCell Reports
Volume34
Issue number12
DOIs
Publication statusPublished - 2021 Mar 23

Keywords

  • ER
  • Hel2
  • SRP
  • mitochondria
  • protein mislocalization
  • protein targeting
  • quality control
  • ribosome collision
  • ribosome stalling
  • ribosome ubiquitination

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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