The relationship of the histologic grade at the deep invasive front and the expression of Ki-67 antigen and p53 protein in oral squamous cell carcinoma

Hideo Kurokawa, Min Zhang, Shinobu Matsumoto, Yoshihiro Yamashita, Toshiko Tanaka, Taiki Tomoyose, Hirofumi Takano, Katsuyuki Funaki, Hiroshi Fukuyama, Tetsu Takahashi, Sumio Sakoda

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

BACKGROUND: Although many histopathologic characteristics of oral squamous cell carcinoma (O-SCC) have been identified as prognostic factors, accurate, and unequivocal factors have not been clearly identified. The purpose of this study was to evaluate a potential association between the histologic grade of malignancy at the deep invasive front and the expression of Ki-67 antigen and p53 protein in O-SCC. METHODS: The expression of Ki-67 antigen and p53 at the invasive tumor front area of O-SCC was examined by immunohistochemistry of archived tissue from 62 cases. The mean age of patients was 60.7 years (range: 37-89) and the male-female ratio was 1.6:1 (38 men, 24 women). There were 20, 17, 14, and 11 cases classified as stage I to stage IV, respectively. The correlation between the intensity of immunostaining for Ki-67 antigen and p53 and the histologic grade of malignancy at the deep invasive front (invasive front grade, IFG) was analyzed. The expression of Ki-67 antigen and p53 in normal oral epithelia (10 cases) was also investigated. RESULTS: The mean Ki-67 labeling index (LI) in the O-SCC samples was 32.8 ± 12.0% (n = 62). The mean total score of IFG (IFG score) was 9.1 ± 2.7 points (n = 62). There was a significant linear correlation between the IFG score and the Ki-67 antigen (γ = 0.651, R2 = 0.596, P < 0.0001). Of 50 tumors examined, 27 (54.0%) exhibited p53-positive nuclear immunostaining. The staining patterns for Ki-67 antigen and p53 were similar. Both Ki-67-LI and p53-positive status were significantly correlated with the IFG scores. CONCLUSION: The findings of this study demonstrate that overexpression of Ki-67 antigen and p53 at the deep tumor invasive front of O-SCC is associated with histologic grade of malignancy.

Original languageEnglish
Pages (from-to)602-607
Number of pages6
JournalJournal of Oral Pathology and Medicine
Volume34
Issue number10
DOIs
Publication statusPublished - 2005 Nov 1
Externally publishedYes

Keywords

  • Deep invasive front
  • Histologic grade of malignancy
  • Ki-67 antigen
  • Oral squamous cell carcinoma
  • p53 protein

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

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