TY - GEN
T1 - The relationship between the arterial geometry and wall shear stress in the vertebrobasilar system
AU - Pan, Fangjia
AU - Anzai, Hitomi
AU - Mugikura, Shunji
AU - Kitamura, Ko
AU - Ohta, Makoto
N1 - Funding Information:
This work was partially supported by KAKENHI (15KK0197), Grand-in-aid A (16H01805), Grand-in-Aid for Young Scientists (18K18355), the OPERA (JST) “Creation of a Development Platform for Implantable/Wearable Medical Devices by a Novel Physiological Data Integration System”, the ImPACT, (JST) “Bionic Humanoids Propelling New Industrial Revolution”, and the AMED under Grant Number 18he1802004h0002 projects. The authors would like to thank Enago (www.enago.jp) for the English language review.
PY - 2019
Y1 - 2019
N2 - Vertebrobasilar atherosclerosis is an arterial disease; without successful treatment, it has a mortality rate approximately 80%–95%. Thus, predicting risk factors of vertebrobasilar atherosclerosis is of utmost importance. Previous studies have demonstrated that wall shear stress (WSS) contributes to atherosclerosis. In addition, geometry and WSS are correlated. The present study focuses on the description of equation using detailed relationship between arterial geometry and WSS in the vertebrobasilar system (VBS); magnetic resonance (MR) imaging with computational fluid dynamics (CFD) was used for the analysis. Using constructed patient-specific models, WSS of basilar arteries (BAs) was calculated and then analyzed with morphological parameters. According to the statistical results, both the area and curvature of BAs are associated with WSS. Based on the relations, a liner fitted equation can be proposed. As this study is underway, more precise evaluation of the correlation between morphology and fluid shear stress could help predict risk factors and select treatment methods for this arterial disease.
AB - Vertebrobasilar atherosclerosis is an arterial disease; without successful treatment, it has a mortality rate approximately 80%–95%. Thus, predicting risk factors of vertebrobasilar atherosclerosis is of utmost importance. Previous studies have demonstrated that wall shear stress (WSS) contributes to atherosclerosis. In addition, geometry and WSS are correlated. The present study focuses on the description of equation using detailed relationship between arterial geometry and WSS in the vertebrobasilar system (VBS); magnetic resonance (MR) imaging with computational fluid dynamics (CFD) was used for the analysis. Using constructed patient-specific models, WSS of basilar arteries (BAs) was calculated and then analyzed with morphological parameters. According to the statistical results, both the area and curvature of BAs are associated with WSS. Based on the relations, a liner fitted equation can be proposed. As this study is underway, more precise evaluation of the correlation between morphology and fluid shear stress could help predict risk factors and select treatment methods for this arterial disease.
KW - Arterial geometries
KW - Computational fluid dynamics (CFD)
KW - Vertebrobasilar system
KW - Wall shear stress
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U2 - 10.1115/IMECE2019-10866
DO - 10.1115/IMECE2019-10866
M3 - Conference contribution
AN - SCOPUS:85078864242
T3 - ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
BT - Biomedical and Biotechnology Engineering
PB - American Society of Mechanical Engineers (ASME)
T2 - ASME 2019 International Mechanical Engineering Congress and Exposition, IMECE 2019
Y2 - 11 November 2019 through 14 November 2019
ER -