The relationship between the arterial geometry and wall shear stress in the vertebrobasilar system

Fangjia Pan, Hitomi Anzai, Shunji Mugikura, Ko Kitamura, Makoto Ohta

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Vertebrobasilar atherosclerosis is an arterial disease; without successful treatment, it has a mortality rate approximately 80%–95%. Thus, predicting risk factors of vertebrobasilar atherosclerosis is of utmost importance. Previous studies have demonstrated that wall shear stress (WSS) contributes to atherosclerosis. In addition, geometry and WSS are correlated. The present study focuses on the description of equation using detailed relationship between arterial geometry and WSS in the vertebrobasilar system (VBS); magnetic resonance (MR) imaging with computational fluid dynamics (CFD) was used for the analysis. Using constructed patient-specific models, WSS of basilar arteries (BAs) was calculated and then analyzed with morphological parameters. According to the statistical results, both the area and curvature of BAs are associated with WSS. Based on the relations, a liner fitted equation can be proposed. As this study is underway, more precise evaluation of the correlation between morphology and fluid shear stress could help predict risk factors and select treatment methods for this arterial disease.

Original languageEnglish
Title of host publicationBiomedical and Biotechnology Engineering
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Electronic)9780791859407
DOIs
Publication statusPublished - 2019
EventASME 2019 International Mechanical Engineering Congress and Exposition, IMECE 2019 - Salt Lake City, United States
Duration: 2019 Nov 112019 Nov 14

Publication series

NameASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
Volume3

Conference

ConferenceASME 2019 International Mechanical Engineering Congress and Exposition, IMECE 2019
CountryUnited States
CitySalt Lake City
Period19/11/1119/11/14

Keywords

  • Arterial geometries
  • Computational fluid dynamics (CFD)
  • Vertebrobasilar system
  • Wall shear stress

ASJC Scopus subject areas

  • Mechanical Engineering

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