The relationship between persistent secretion of RANTES and residual infiltration of eosinophils and memory T lymphocytes after Helicobacter pylori eradication

Tohru Kikuchi, Katsuaki Kato, Shuichi Ohara, Hitoshi Sekine, Tadashi Arikawa, Tatsuhiko Suzuki, Kenji Noguchi, Michiya Saito, Yasutoshi Saito, Hiroshi Nagura, Takayoshi Toyota, Tooru Shimosegawa

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Helicobacter pylori (HP)-infected gastric mucosa displays a conspicuous infiltration of mononuclear cells as well as neutrophils. RANTES is a potent chemoattractant peptide for memory T lymphocytes and eosinophils. RANTES protein concentration and the numbers of RANTES-, CD45RO-, and major basic protein (MBP)-positive cells were therefore evaluated in the gastric mucosa from 51 patients with HP-positive chronic gastritis before and after HP eradication and from 22 HP-negative healthy volunteers. RANTES protein concentration was significantly elevated in HP-positive cases and remained high after HP eradication. The numbers of RANTES-, CD45RO-, and MBP-positive cells were significantly increased in HP-positive cases and were well correlated with RANTES protein levels. All tended to decrease after HP eradication, but did not reach the level of HP-negative cases, even at 24 months after HP eradication. It was concluded that persistent expression and secretion of RANTES were closely related to residual infiltration of memory T lymphocytes and eosinophils, for a prolonged period after HP eradication. This seems to be an important mechanism of prolonged gastric mucosal immune response against HP infection, even after HP eradication, and of persistent mucosal damage and atrophy. Copyright (C) 2000 John Wiley and Sons, Ltd.

Original languageEnglish
Pages (from-to)243-250
Number of pages8
JournalJournal of Pathology
Volume192
Issue number2
DOIs
Publication statusPublished - 2000

Keywords

  • Eosinophils
  • Gastritis
  • HP eradication
  • Helicobacter pylori
  • Memory T lymphocytes
  • RANTES

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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