TY - JOUR
T1 - The relationship between persistent secretion of RANTES and residual infiltration of eosinophils and memory T lymphocytes after Helicobacter pylori eradication
AU - Kikuchi, Tohru
AU - Kato, Katsuaki
AU - Ohara, Shuichi
AU - Sekine, Hitoshi
AU - Arikawa, Tadashi
AU - Suzuki, Tatsuhiko
AU - Noguchi, Kenji
AU - Saito, Michiya
AU - Saito, Yasutoshi
AU - Nagura, Hiroshi
AU - Toyota, Takayoshi
AU - Shimosegawa, Tooru
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2000
Y1 - 2000
N2 - Helicobacter pylori (HP)-infected gastric mucosa displays a conspicuous infiltration of mononuclear cells as well as neutrophils. RANTES is a potent chemoattractant peptide for memory T lymphocytes and eosinophils. RANTES protein concentration and the numbers of RANTES-, CD45RO-, and major basic protein (MBP)-positive cells were therefore evaluated in the gastric mucosa from 51 patients with HP-positive chronic gastritis before and after HP eradication and from 22 HP-negative healthy volunteers. RANTES protein concentration was significantly elevated in HP-positive cases and remained high after HP eradication. The numbers of RANTES-, CD45RO-, and MBP-positive cells were significantly increased in HP-positive cases and were well correlated with RANTES protein levels. All tended to decrease after HP eradication, but did not reach the level of HP-negative cases, even at 24 months after HP eradication. It was concluded that persistent expression and secretion of RANTES were closely related to residual infiltration of memory T lymphocytes and eosinophils, for a prolonged period after HP eradication. This seems to be an important mechanism of prolonged gastric mucosal immune response against HP infection, even after HP eradication, and of persistent mucosal damage and atrophy. Copyright (C) 2000 John Wiley and Sons, Ltd.
AB - Helicobacter pylori (HP)-infected gastric mucosa displays a conspicuous infiltration of mononuclear cells as well as neutrophils. RANTES is a potent chemoattractant peptide for memory T lymphocytes and eosinophils. RANTES protein concentration and the numbers of RANTES-, CD45RO-, and major basic protein (MBP)-positive cells were therefore evaluated in the gastric mucosa from 51 patients with HP-positive chronic gastritis before and after HP eradication and from 22 HP-negative healthy volunteers. RANTES protein concentration was significantly elevated in HP-positive cases and remained high after HP eradication. The numbers of RANTES-, CD45RO-, and MBP-positive cells were significantly increased in HP-positive cases and were well correlated with RANTES protein levels. All tended to decrease after HP eradication, but did not reach the level of HP-negative cases, even at 24 months after HP eradication. It was concluded that persistent expression and secretion of RANTES were closely related to residual infiltration of memory T lymphocytes and eosinophils, for a prolonged period after HP eradication. This seems to be an important mechanism of prolonged gastric mucosal immune response against HP infection, even after HP eradication, and of persistent mucosal damage and atrophy. Copyright (C) 2000 John Wiley and Sons, Ltd.
KW - Eosinophils
KW - Gastritis
KW - HP eradication
KW - Helicobacter pylori
KW - Memory T lymphocytes
KW - RANTES
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U2 - 10.1002/1096-9896(2000)9999:9999<::AID-PATH688>3.0.CO;2-D
DO - 10.1002/1096-9896(2000)9999:9999<::AID-PATH688>3.0.CO;2-D
M3 - Article
C2 - 11004702
AN - SCOPUS:0033780286
VL - 192
SP - 243
EP - 250
JO - Journal of Pathology
JF - Journal of Pathology
SN - 0022-3417
IS - 2
ER -