The Relationship between Mismatch Negativity and the COMT Val108/158Met Genotype in Schizophrenia

Sho Horikoshi, Tetsuya Shiga, Hiroshi Hoshino, Haruka Ochiai, Keiko Kanno-Nozaki, Kazuko Kanno, Haruka Kaneko, Yasuto Kunii, Itaru Miura, Hirooki Yabe

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Mismatch negativity (MMN) is a component of auditory event-related potentials that reflects automatic change detection in the brain, showing qualities of endophenotypes in schizophrenia. MMN deficiency is one of the robust findings in patients, and it reflects both cognitive and functional decline. Catechol-o-methyltransferase (COMT) is a key enzyme involved in regulating dopamine transmission within the prefrontal cortex. A preliminary study suggested that the COMTVal108/158Met genotype (rs4680) is related to cognitive function in schizophrenia. Both the COMTVal108/158Met genotype and MMN are related to cognitive function, but no studies have reported on the relationship between MMN and the COMTVal108/158Met genotype in schizophrenia. This study therefore examined the relationship between COMTVal108/158Met genotype and MMN. The duration of MMN was measured, and the COMTVal108/158Met polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in 49 Japanese schizophrenia patients (Val/Val, n = 21; Met carriers, n = 28). Amplitude and latency of MMN were compared between Val/Val and Met carriers.

Original languageEnglish
Pages (from-to)192-196
Number of pages5
Issue number4
Publication statusPublished - 2019 Apr 1
Externally publishedYes


  • Catechol-o-methyltransferase
  • COMTVal108/158Met
  • Event-related potential
  • Gene
  • Mismatch negativity
  • Schizophrenia

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry


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