The relationship between choroidal blood flow and glaucoma progression in a Japanese study population

Naoki Kiyota, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa

Research output: Contribution to journalArticlepeer-review


Purpose: To determine whether choroidal blood flow (BF) is related to visual field (VF) defect severity and progression in eyes with open-angle glaucoma (OAG). Study design: Retrospective and longitudinal. Methods: This study comprised 443 eyes of 285 OAG patients who underwent laser speckle flowgraphy (LSFG), optical coherence tomography, and visual-field (VF) testing at baseline. The patients were then observed for at least 2 years and at least 5 reliable VF tests were performed. In the LSFG images, we set regions of interest at the optic nerve head (ONH) and the parapapillary choroid to obtain ONH-tissue mean blur rate (MBR) and choroidal MBR, respectively. We used univariable and multivariable linear mixed-effects models to determine clinical factors associated with choroidal MBR at baseline. We also used a linear mixed-effects model to determine the contribution of ONH-tissue MBR and choroidal MBR to baseline mean deviation (MD) and to MD slope during follow-up, adjusting for potential confounding factors, including circumpapillary retinal nerve fiber layer thickness. Results: Choroidal MBR was associated with age, MD slope, and ONH-tissue MBR (β = -0.181, P = 0.001; β = 0.134, P = 0.002; β = 0.096, P = 0.049, respectively). ONH-tissue MBR was associated with both MD and MD slope (β = 0.146, P = 0.004; β = 0.152, P = 0.009, respectively), whereas choroidal MBR was associated only with MD slope (β = 0.147, P = 0.005). Conclusion: LSFG-derived choroidal MBR might be a useful biomarker to predict VF defect progression in a Japanese population.

Original languageEnglish
Pages (from-to)425-433
Number of pages9
JournalJapanese Journal of Ophthalmology
Issue number5
Publication statusPublished - 2022 Sept


  • Choroid
  • Ocular blood flow
  • Open-angle glaucoma

ASJC Scopus subject areas

  • Ophthalmology


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