The relationship between body mass index and a plasma lipid peroxidation biomarker in an older, healthy Asian community

Kaori Ohmori, Satoru Ebihara, Shinichi Kuriyama, Takashi Ugajin, Mikiko Ogata, Atsushi Hozawa, Toshifumi Matsui, Yoshitaka Tsubono, Hiroyuki Arai, Hidetada Sasaki, Ichiro Tsuji

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

To examine the association between body mass index (BMI) and the plasma level of a lipid peroxidation biomarker in a large sample of elderly healthy Asian population. This cross-sectional study included 1150 community-dwelling Japanese aged 70 years or older in 2002. We measured the lipid peroxidation biomarker 8-iso-prostaglandin F (8-iso-PGF ) using the ELISA method. We also measured the weight and height and calculated the BMI as weight (kg)/height (m) 2. After adjustment for potential confounders, the mean ± SE plasma 8-iso-PGF level was significantly higher in subjects with higher BMI: 21.1 ± 0.8 pg/ml in those with BMI of 30.0 or more; 20.5 ± 0.3 pg/ml in those with BMI between 25.0 and 29.9; 20.0 ± 0.2 pg/ml in those with BMI between 18.5 and 24.9; and 19.0 ± 0.7 pg/ml in those with BMI of less than 18.5 (p for trend = 0.011). Our results demonstrated that in the healthy Asian population, there was a modest but significant relationship between BMI and the plasma lipid peroxidation level.

Original languageEnglish
Pages (from-to)80-84
Number of pages5
JournalAnnals of Epidemiology
Volume15
Issue number1
DOIs
Publication statusPublished - 2005 Jan
Externally publishedYes

Keywords

  • Aged
  • Asia
  • Body Mass Index
  • Isoprostanes
  • Obesity
  • Oxidative Stress

ASJC Scopus subject areas

  • Epidemiology

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