The relationship between growth hormone and testosterone (T) 6β-hydroxylase was investigated in normal and hypophysectomized (hypox) male rats. The administration of human growth hormone (hGH) by either intermittent injections or continuous infusion to normal and hypox rats decreased the activity of T 6β-hydroxylase in hepatic microsomes. Hypophysectomy did not reduce, but rather increased the 6β-hydroxylase activity, while the 16α-hydroxylase activity decreased. These results, together with the data from a Western blot, indicate that growth hormone acts as a repressive factor for the expression of T 6β-hydroxylase in a manner different from the regulation of T 16α-hydroxylase.
|Number of pages||3|
|Journal||Journal of biochemistry|
|Publication status||Published - 1986 Oct|
ASJC Scopus subject areas
- Molecular Biology