The regulation by growth hormone of microsomal testosterone 6β-hydroxylase in male rat livers

Yasushi Yamazoe, Miki Shimada, Norie Murayama, Sumie Kawano, Ryuichi Kato

    Research output: Contribution to journalArticlepeer-review

    52 Citations (Scopus)

    Abstract

    The relationship between growth hormone and testosterone (T) 6β-hydroxylase was investigated in normal and hypophysectomized (hypox) male rats. The administration of human growth hormone (hGH) by either intermittent injections or continuous infusion to normal and hypox rats decreased the activity of T 6β-hydroxylase in hepatic microsomes. Hypophysectomy did not reduce, but rather increased the 6β-hydroxylase activity, while the 16α-hydroxylase activity decreased. These results, together with the data from a Western blot, indicate that growth hormone acts as a repressive factor for the expression of T 6β-hydroxylase in a manner different from the regulation of T 16α-hydroxylase.

    Original languageEnglish
    Pages (from-to)1095-1097
    Number of pages3
    JournalJournal of biochemistry
    Volume100
    Issue number4
    DOIs
    Publication statusPublished - 1986 Oct

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology

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