The redox state of albumin and serious cardiovascular incidence in hemodialysis patients

Hiroyuki Terawaki, Yukie Takada, Seiichi Era, Yoichi Funakoshi, Keisuke Nakayama, Masaaki Nakayama, Makoto Ogura, Sadayoshi Ito, Tatsuo Hosoya

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Human serum albumin is composed of human mercaptoalbumin (HMA) with cysteine residues having reducing powers and oxidized human non-mercaptoalbumin. The aim of this study is to clarify whether such redox state of albumin (HSA-redox) influences the incidence of cardiovascular disease (CVD) in chronic kidney disease patients on regular hemodialysis (HD). We measured HSA-redox using high-performance liquid chromatography in 86 anuric HD patients. The association between HSA-redox and incidental CVD events was evaluated. Twenty patients experienced symptomatic CVD events (16 patients died) at the 2-year follow-up. The fraction of HMA (f(HMA)) showed a significantly lower value in patients with CVD than that without CVD, in both pre-HD (36.5 ± 5.8% and 44.6 ± 9.8%, respectively) and post-HD (57.2 ± 6.2% and 67.2 ± 7.4%, respectively). The adjusted odds ratio (OR) for the incidental CVD event in patients with pre-HD f(HMA) < 40% was 5.0 (95% CI; 1.2 to 21.3), and that in patients with post-HD f(HMA) < 60% was 20.6 (3.2 to 134.7). Likewise, the adjusted OR for the CVD death in patients with pre-HD f(HMA) < 40% was 2.5 (0.6 to 12.5), and that in patients with post-HD f(HMA) < 60% was 25.6 (2.5 to 262.8). In conclusion, HSA-redox is closely related to serious CVD incidence and mortality among HD patients.

Original languageEnglish
Pages (from-to)465-471
Number of pages7
JournalTherapeutic Apheresis and Dialysis
Volume14
Issue number5
DOIs
Publication statusPublished - 2010 Oct

Keywords

  • Cardiovascular disease
  • Hemodialysis
  • Oxidative stress
  • Redox state of albumin

ASJC Scopus subject areas

  • Hematology
  • Nephrology

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