The quest for a more acceptable bowel preparation: Comparison of a polyethylene glycol/electrolyte solution and a mannitol/Picolax mixture for colonoscopy

Brian P. Saunders, Tadahiko Masaki, Manabu Fukumoto, Steven Halligan, Christopher B. Williams

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Eighty-nine consecutive patients attending for day-case colonoscopy were randomly allocated either polyethylene glycol/balanced electrolyte (PEG) mixture (n = 45) or a mannitol/Picolax mixture (n = 44). Both preparations were administered in two fractions. Patients recorded their experience of the preparation on a questionnaire and one of two experienced endoscopists (unaware of the type of preparation given) assessed the result of bowel cleansing. Carbon dioxide insufflation was used for all examinations. Good/excellent bowel cleansing occurred in significantly more patients given PEG, 43 (96%), than those allocated mannitol/Picolax, 34 (77%), p = 0.01. More patients receiving mannitol/Picolax were able to complete the preparation in full than patients receiving PEG (38 vs 27, p = 0.01). More patients found the taste of mannitol/Picolax pleasant compared to PEG (46% vs 20%). Both preparations had a similar side-effect profile. Of those patients tested, 13% receiving mannitol/Picolax had a postural drop in blood pressure and blood parameters suggestive of mild dehydration. A fractionated administration of PEG as a bowel preparation for day-case colonoscopy is well tolerated and superior as a cleansing agent to a mannitol/Picolax combination. Provided carbon dioxide is used as the insufflating agent, mannitol/Picolax is an acceptable alternative in fit, young patients intolerant of PEG.

Original languageEnglish
Pages (from-to)476-479
Number of pages4
JournalPostgraduate Medical Journal
Volume71
Issue number838
DOIs
Publication statusPublished - 1995

Keywords

  • Bowel cleansing
  • Colonoscopy

ASJC Scopus subject areas

  • Medicine(all)

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