The PTEN, BAX, and IGFIIR genes are mutated in endometrial atypical hyperplasia

Kousuke Yoshinaga, Hironobu Sasano, Toru Furukawa, Hiromitsu Yamakawa, Michihiro Yuki, Shinji Sato, Akira Yajima, Akira Horii

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

To pursue the pathogenesis of endometrial carcinogenesis, we investigated microsatellite instability mutations in the PTEN, TGF βRII, IGFIIR, and BAX genes, and LOHs on 10q in 18 putative endometrial premalignant lesions (11 endometrial atypical hyperplasias (ATHs), 2 complex hyperplasias, and 5 simple hyperplasias) as well as 8 endometrial cancers (ECs). In the ATH cases, MSIs as well as LOHs at 10q were observed at frequencies similar to those in ECs. Mutations in PTEN, BAX, and IGFIIR were observed only in ATHs and ECs. These results suggest that (1) PTEN, BAX, and IGFIIR are already mutated in ATHs, and (2) ATH is one of the precursor lesions which could lead to EC.

Original languageEnglish
Pages (from-to)985-990
Number of pages6
JournalJapanese Journal of Cancer Research
Volume89
Issue number10
DOIs
Publication statusPublished - 1998 Oct

Keywords

  • BAX
  • Endometrial hyperplasia
  • IGFIIR
  • MSI
  • PTEN

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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