The P/S Ratio of Dietary Fats and Lipid Metabolism in Rats: Gamma-linolenic Acid as a Source of Polyunsaturated Fatty Acid

Joon Ho Lee, Shihomi Taguchi, Ikuo Ikeda, Michihiro Sugano

Research output: Contribution to journalArticle

Abstract

The effects of different dietary levels of gamma-linolenic acid (GLA) on lipid metabolism was studied in rats using a combination of evening primrose oil (EPO) and palm oil (PLO). EPO compared to PLO significantly reduced liver cholesterol and triglyceride after 4 weeks of feeding, and the effect remained even when EPO was mixed with PLO at the same weight basis. The serum triglyceride level also tended to be low on feeding EPO. Neither liver Δ6-desaturase and phospholipase A2 activities nor aortic production of prostacyclin and thromboxane A2 production by platelets were influenced significantly by the fat type, suggesting a peculiar effect of PLO. The percentage of arachidonic acid in liver, serum, and aortic phosphatidylcholine depended on the dietary level of GLA. A more distinct increase in arachidonic acid was observed in tissue triglycerides of rats fed EPO. GLA appears to exert favorable effects on lipid metabolism even when the P/S ratio was lowered from 13.7 of EPO to 1.8 of the 1:1 mixture of EPO and PLO.

Original languageEnglish
Pages (from-to)3137-3142
Number of pages6
JournalAgricultural and Biological Chemistry
Volume52
Issue number12
DOIs
Publication statusPublished - 1988 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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