The Prognostic Value of E-Cadherin, α-, β-, and γ-Catenin in Urothelial Cancer of the Upper Urinary Tract

Keishi Kashibuchi, Kyoichi Tomita, Jack A. Schalken, Haruki Kume, Takuhiro Yamaguchi, Satoru Muto, Sigeo Horie, Tadaichi Kitamura

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Objectives: To determine the value of loss of the expression of E-cadherin and cadherin-associated molecules as useful markers for both prognosis and bladder recurrence in patients with upper urinary tract cancer. Materials and methods: In 61 paraffin-embedded nephroureterectomy specimens, the expression of E-cadherin and α-, β-, and γ-catenin was examined by immunohistochemical staining. To evaluate the prognostic significance, Kaplan-Meier survival curves were calculated and compared by the log-rank test. A multivariate test was performed to detect prognostic markers. Results: Normal expression was found in 32 cases (52.5%) for E-cadherin, 41 cases (67.2%) for α-catenin, 42 cases (68.9%) for β-catenin, and 31 cases (50.8%) for γ-catenin. The expression patterns of E-cadherin and α-, β- and γ-catenin were significantly correlated with each other. Survival analysis showed a significant difference between normal and aberrant expression in each staining. Multivariate analysis revealed that tumor stage and the expression of E-cadherin were independent prognostic factors for cause-specific survival. In contrast, there was no significant correlation between the expression of E-cadherin and α-, β-, and γ-catenin and bladder recurrence. Conclusion: Our data suggest E-cadherin may be a good prognostic marker for patients with upper urinary tract cancer.

Original languageEnglish
Pages (from-to)839-845
Number of pages7
JournalEuropean Urology
Volume49
Issue number5
DOIs
Publication statusPublished - 2006 May 1
Externally publishedYes

Keywords

  • Bladder recurrence
  • Catenin
  • E-cadherin
  • Prognostic factor
  • Upper urinary tract
  • Urothelial cancer

ASJC Scopus subject areas

  • Urology

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