Abstract
A new precursor, 11C-guanidine, for the synthesis of 11C-radiopharmaceuticals was produced by the proton irradiation of the liquid NH3N2O system. The optimal ratio of NH3 and N2O was obtained at a 5 μA-30 min irradiation. The maximum yield of 11C-guanidine was about 42% at 69 mmol of N2O per 200 mmol of NH3. The synthesis of 2-amino[2-11C]pyrimidines was carried out by using 11C-guanidine and the optimal reaction conditions were determined. The radiochemical yields of the three 11C-pyrimidines were about 70-100%. It was shown that trimethinium salts are suitable for the synthesis of 11C-pyrimidines from 11C-guanidine.
Original language | English |
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Pages (from-to) | 303-308 |
Number of pages | 6 |
Journal | The International Journal Of Applied Radiation And Isotopes |
Volume | 32 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1981 May |
ASJC Scopus subject areas
- Radiation
- Nuclear Energy and Engineering
- Radiology Nuclear Medicine and imaging