The production of 11C-guanidine by the proton irradiation of the liquid ammonia-nitrous oxide system and its use in the synthesis of 11C-pyrimidines

Iwata Ren Iwata; Ido Tatsuo Ido; Tominaga Takeshi Tominaga

doi:10.1016/0020-708X(81)90090-9

The production of ¹¹C-guanidine by the proton irradiation of the liquid ammonia-nitrous oxide system and its use in the synthesis of ¹¹C-pyrimidines

Iwata Ren Iwata, Ido Tatsuo Ido, Tominaga Takeshi Tominaga

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A new precursor, ¹¹C-guanidine, for the synthesis of ¹¹C-radiopharmaceuticals was produced by the proton irradiation of the liquid NH₃N₂O system. The optimal ratio of NH₃ and N₂O was obtained at a 5 μA-30 min irradiation. The maximum yield of ¹¹C-guanidine was about 42% at 69 mmol of N₂O per 200 mmol of NH₃. The synthesis of 2-amino[2-¹¹C]pyrimidines was carried out by using ¹¹C-guanidine and the optimal reaction conditions were determined. The radiochemical yields of the three ¹¹C-pyrimidines were about 70-100%. It was shown that trimethinium salts are suitable for the synthesis of ¹¹C-pyrimidines from ¹¹C-guanidine.

Original language	English
Pages (from-to)	303-308
Number of pages	6
Journal	The International Journal Of Applied Radiation And Isotopes
Volume	32
Issue number	5
DOIs	https://doi.org/10.1016/0020-708X(81)90090-9
Publication status	Published - 1981 May

ASJC Scopus subject areas

Radiation
Nuclear Energy and Engineering
Radiology Nuclear Medicine and imaging

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The production of ¹¹C-guanidine by the proton irradiation of the liquid ammonia-nitrous oxide system and its use in the synthesis of ¹¹C-pyrimidines. / Ren Iwata, Iwata; Tatsuo Ido, Ido; Takeshi Tominaga, Tominaga.

In: The International Journal Of Applied Radiation And Isotopes, Vol. 32, No. 5, 05.1981, p. 303-308.

Research output: Contribution to journal › Article › peer-review

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title = "The production of 11C-guanidine by the proton irradiation of the liquid ammonia-nitrous oxide system and its use in the synthesis of 11C-pyrimidines",

abstract = "A new precursor, 11C-guanidine, for the synthesis of 11C-radiopharmaceuticals was produced by the proton irradiation of the liquid NH3N2O system. The optimal ratio of NH3 and N2O was obtained at a 5 μA-30 min irradiation. The maximum yield of 11C-guanidine was about 42% at 69 mmol of N2O per 200 mmol of NH3. The synthesis of 2-amino[2-11C]pyrimidines was carried out by using 11C-guanidine and the optimal reaction conditions were determined. The radiochemical yields of the three 11C-pyrimidines were about 70-100%. It was shown that trimethinium salts are suitable for the synthesis of 11C-pyrimidines from 11C-guanidine.",

author = "{Ren Iwata}, Iwata and {Tatsuo Ido}, Ido and {Takeshi Tominaga}, Tominaga",

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T1 - The production of 11C-guanidine by the proton irradiation of the liquid ammonia-nitrous oxide system and its use in the synthesis of 11C-pyrimidines

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AU - Tatsuo Ido, Ido

AU - Takeshi Tominaga, Tominaga

PY - 1981/5

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N2 - A new precursor, 11C-guanidine, for the synthesis of 11C-radiopharmaceuticals was produced by the proton irradiation of the liquid NH3N2O system. The optimal ratio of NH3 and N2O was obtained at a 5 μA-30 min irradiation. The maximum yield of 11C-guanidine was about 42% at 69 mmol of N2O per 200 mmol of NH3. The synthesis of 2-amino[2-11C]pyrimidines was carried out by using 11C-guanidine and the optimal reaction conditions were determined. The radiochemical yields of the three 11C-pyrimidines were about 70-100%. It was shown that trimethinium salts are suitable for the synthesis of 11C-pyrimidines from 11C-guanidine.

AB - A new precursor, 11C-guanidine, for the synthesis of 11C-radiopharmaceuticals was produced by the proton irradiation of the liquid NH3N2O system. The optimal ratio of NH3 and N2O was obtained at a 5 μA-30 min irradiation. The maximum yield of 11C-guanidine was about 42% at 69 mmol of N2O per 200 mmol of NH3. The synthesis of 2-amino[2-11C]pyrimidines was carried out by using 11C-guanidine and the optimal reaction conditions were determined. The radiochemical yields of the three 11C-pyrimidines were about 70-100%. It was shown that trimethinium salts are suitable for the synthesis of 11C-pyrimidines from 11C-guanidine.

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