The production of 11C-guanidine by the proton irradiation of the liquid ammonia-nitrous oxide system and its use in the synthesis of 11C-pyrimidines

Iwata Ren Iwata, Ido Tatsuo Ido, Tominaga Takeshi Tominaga

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    A new precursor, 11C-guanidine, for the synthesis of 11C-radiopharmaceuticals was produced by the proton irradiation of the liquid NH3N2O system. The optimal ratio of NH3 and N2O was obtained at a 5 μA-30 min irradiation. The maximum yield of 11C-guanidine was about 42% at 69 mmol of N2O per 200 mmol of NH3. The synthesis of 2-amino[2-11C]pyrimidines was carried out by using 11C-guanidine and the optimal reaction conditions were determined. The radiochemical yields of the three 11C-pyrimidines were about 70-100%. It was shown that trimethinium salts are suitable for the synthesis of 11C-pyrimidines from 11C-guanidine.

    Original languageEnglish
    Pages (from-to)303-308
    Number of pages6
    JournalThe International Journal Of Applied Radiation And Isotopes
    Volume32
    Issue number5
    DOIs
    Publication statusPublished - 1981 May

    ASJC Scopus subject areas

    • Radiation
    • Nuclear Energy and Engineering
    • Radiology Nuclear Medicine and imaging

    Fingerprint Dive into the research topics of 'The production of <sup>11</sup>C-guanidine by the proton irradiation of the liquid ammonia-nitrous oxide system and its use in the synthesis of <sup>11</sup>C-pyrimidines'. Together they form a unique fingerprint.

    Cite this