The primacy of octacalcium phosphate collagen composites in bone regeneration

Shinji Kamakura, Kazuo Sasaki, Takahiro Homma, Yoshitomo Honda, Takahisa Anada, Seishi Echigo, Osamu Suzuki

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

We have engineered a scaffold constructed of synthetic octacalcium phosphate (OCP) and porcine collagen sponge (OCP/Col), and reported that OCP/Col drastically enhanced bone regeneration. In this study, we investigated whether OCP/Col would enhance bone regeneration more than β-tricalcium phosphate (β-TCP) collagen composite (β-TCP/Col) or hydroxyapatite (HA) collagen composite (HA/Col). Discs of OCP/Col, β-TCP/Col, or HA/Col were implanted into critical-sized defects in rat crania and fixed at 4 or 12 weeks after implantation. The newly formed bone and the remaining granules of implants in the defect were determined by histomorphometrical analysis, and radiographic and histological examinations were performed. Statistical analysis showed that the newly formed bone by the implantation of OCP/Col was significantly more than that of β-TCP/Col or HA/Col. In contrast, the remaining granules in OCP/Col were significantly lower than those in β-TCP/Col or HA/Col. Bone regeneration by OCP/Col was based on secured calcified collagen and bone nucleation by OCP, whereas bone regeneration by β-TCP/Col or HA/Col was initiated by poorly calcified collagen and osteoconductivity by β-TCP or HA. This study showed that the implantation of OCP/Col in a rat cranial defect enhanced more bone regeneration than β-TCP/Col and HA/Col.

Original languageEnglish
Pages (from-to)725-733
Number of pages9
JournalJournal of Biomedical Materials Research - Part A
Volume83
Issue number3
DOIs
Publication statusPublished - 2007 Nov 1

Keywords

  • Bone regeneration
  • Collagen
  • Hydroxyapatite
  • Octacalcium phosphate
  • β-tricalcium phosphate

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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