The prevalence of intrinsic subtypes and prognosis in breast cancer patients of different races

Junichi Kurebayashi, Takuya Moriya, Takanori Ishida, Hisashi Hirakawa, Masafumi Kurosumi, Futoshi Akiyama, Takayuki Kinoshita, Hiroyuki Takei, Kaoru Takahashi, Masahiko Ikeda, Kazutaka Nakashima

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

A recent report indicated that a high prevalence of basal-like breast tumors (estrogen receptor [ER]-negative, progesterone receptor [PR]-negative, human epidermal growth factor receptor [HER] 2-negative, and cytokeratin 5/6-positive and/or HER1-positive) could contribute to a poor prognosis in African American women with breast cancer. It has been reported that Japanese women with breast cancer have a significantly better survival rate than other races in the USA. These findings suggest that breast cancers in Japanese women have favorable biological characteristics. To clarify this hypothesis, we conducted a cohort study to investigate the prevalence of intrinsic subtypes and prognosis for each subtype in 793 Japanese patients. This study revealed a very low prevalence (only 8%) of basal-like breast tumors with aggressive biological characteristics in Japanese patients. Survival analysis showed a significantly poorer prognosis in patients with basal-like tumors than in those with luminal A tumors (ER- and/or PR-positive, and HER2-negative) with favorable biological characteristics. These findings support the hypothesis that breast cancers in Japanese women have more favorable biological characteristics and a better prognosis than those in other races. In conclusion, the prevalence of basal-like breast tumors could influence the prognosis of breast cancer patients of different races. The prevalence of intrinsic subtypes should be taken into account when analyzing survival data in a multi-racial/international clinical study.

Original languageEnglish
Pages (from-to)72-77
Number of pages6
JournalBreast
Volume16
Issue number2 SUPPL.
DOIs
Publication statusPublished - 2007 Jan 1

Keywords

  • Breast cancer
  • Intrinsic subtype
  • Japanese
  • Prevalence
  • Prognosis
  • Triple-negative tumor

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'The prevalence of intrinsic subtypes and prognosis in breast cancer patients of different races'. Together they form a unique fingerprint.

  • Cite this

    Kurebayashi, J., Moriya, T., Ishida, T., Hirakawa, H., Kurosumi, M., Akiyama, F., Kinoshita, T., Takei, H., Takahashi, K., Ikeda, M., & Nakashima, K. (2007). The prevalence of intrinsic subtypes and prognosis in breast cancer patients of different races. Breast, 16(2 SUPPL.), 72-77. https://doi.org/10.1016/j.breast.2007.07.017