The possible involvement of CXCR4 in the inhibition of HIV-1 infection mediated by DP178/gp41

Younong Xu, Xiaoyan Zhang, Masao Matsuoka, Toshio Hattori

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The N- (N36/DP107) and C-terminal peptides (C34/DP178) from two α-helical domains of human immunodeficiency virus type 1 (HIV-1) gp41 inhibited HIV infection. A single-round infection using pseudotyped virus clarified that a greater amount of gp41-derived peptides was necessary for the inhibition of R5 virus (ADA) infection than for that of X4 virus (LAI) infection. Furthermore, R5X4 virus (89.6) infection via CCR5 needs more peptides for inhibition than its infection via CXCR4 does. A high sensitivity of X4 virus was partially ascribed to the inhibition of the 12G5 binding to CXCR4 by DP178LAI.

Original languageEnglish
Pages (from-to)185-188
Number of pages4
JournalFEBS Letters
Volume487
Issue number2
DOIs
Publication statusPublished - 2000 Dec 29

Keywords

  • R5 virus
  • R5X4 virus
  • X4 virus
  • gp41-derived peptide

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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