The plasma leak-to-response hypothesis: A working hypothesis on the pathogenesis of encapsulating peritoneal sclerosis after long-term peritoneal dialysis treatment

Masaaki Nakayama

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Encapsulating peritoneal sclerosis (EPS) is one of the most serious complications of long-term peritoneal dialysis (PD). Long-term PD therapy has been suggested as a risk factor for EPS development among patients in Japan and Australia. Although the primary mechanism of EPS development has not been clarified, histologic changes of the peritoneum associated with prolonged PD are postulated to be causally related. The present article proposes a working hypothesis - the plasma leak-to-response hypothesis - that vascular alterations in the peritoneum of long-term PD patients play a crucial rote in the initiation and development of EPS.

Original languageEnglish
Pages (from-to)S71-S76
JournalPeritoneal Dialysis International
Volume25
Issue numberSUPPL. 4
DOIs
Publication statusPublished - 2005 Apr

Keywords

  • EPS
  • Encapsulating peritoneal sclerosis
  • High transporter
  • Plasma leak-to-response hypothesis

ASJC Scopus subject areas

  • Nephrology

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