The perfusion defect seen with SPECT in West syndrome is not correlated with seizure prognosis or developmental outcome

Kazuhiro Haginoya, Kimiya Kon, Hiroyuki Yokoyama, Soichiro Tanaka, Rie Kato, Mitsutoshi Munakata, Tsuneo Yagi, Masaru Takayanagi, Yasushi Yoshihara, Mayumi Nagai, Tetsuro Yamazaki, Shin Maruoka, Kazuie Iinuma

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

We used interictal single photon emission computed tomography (SPECT) on 40 patients with West syndrome to determine whether cortical perfusion abnormalities are closely related to the development of West syndrome and whether they are correlated with the long-term seizure prognosis or the developmental outcome. Localized cortical perfusion abnormalities were seen in 24 patients (60%), while 15 patients (38%) were classified as normal. The remaining patient showed hyperperfusion of the basal ganglia bilaterally. Of 24 patients with localized perfusion abnormalities, unifocal cortical hypoperfusion was present in 11, multifocal hypoperfusion in 10, multiple cortical hypo- and hyperperfusion in one, hyperperfusion of the bilateral frontal cortices and brain stem in one, and focal hyperperfusion in the residual frontal cortex in one. For statistical analysis, we focused on 26 patients (cryptogenic; 10, symptomatic; 16), who were followed for more than 2 years after the onset of tonic spasms (mean 5.0 years). The results showed that focal cortical perfusion abnormalities were not correlated with the long-term seizure prognosis, the developmental outcome, or the response to ACTH therapy. In agreement with previous reports, the results of interictal SPECT suggested that focal cortical lesions play an important role in the development of West syndrome. However, statistical analysis showed that the existence of cortical dysfunction as defined by SPECT did not predict the seizure prognosis or the developmental outcome. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)16-23
Number of pages8
JournalBrain and Development
Volume22
Issue number1
DOIs
Publication statusPublished - 2000 Jan 1

Keywords

  • Epilepsy
  • Infantile spasms
  • SPECT
  • Tonic spasms
  • West syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

Fingerprint Dive into the research topics of 'The perfusion defect seen with SPECT in West syndrome is not correlated with seizure prognosis or developmental outcome'. Together they form a unique fingerprint.

Cite this