The p75 receptor mediates axon growth inhibition through an association with PIR-B

Y. Fujita, R. Takashima, S. Endo, T. Takai, T. Yamashita

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

The Nogo receptor and paired immunoglobulin-like receptor B (PIR-B) are receptors for three myelin-derived axon-growth inhibitors, including myelin-associated glycoprotein (MAG). In this study, we report that the p75 receptor is required for the signal transduction of PIR-B, which interacted with p75 upon ligand binding. In addition, p75 was required for activation of Src homology 2-containing protein tyrosine phosphatase (SHP), which is induced by MAG binding to PIR-B. Mice carrying a mutation in the p75 gene showed promotion of axonal regeneration after optic nerve injury. Thus, our results indicate that p75 has a critical role in axon growth inhibition in specific neuronal tracts.

Original languageEnglish
Pages (from-to)e198
JournalCell Death and Disease
Volume2
Issue number9
DOIs
Publication statusPublished - 2011 Sep

Keywords

  • Axon regeneration
  • MAG
  • P75
  • PIR-B

ASJC Scopus subject areas

  • Immunology
  • Cellular and Molecular Neuroscience
  • Cell Biology
  • Cancer Research

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