The nucleosomal binding protein NSBP1 is highly expressed in the placenta and modulates the expression of differentiation markers in placental Rcho-1 cells

Hitoshi Shirakawa, Mark Rochman, Takashi Furusawa, Michael R. Kuehn, Satoru Horigome, Keiichi Haketa, Yumi Sugita, Tomoyuki Inada, Michio Komai, Michael Bustin

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

We report that NSBP1, a nucleosome binding protein that affects the structure of chromatin, is highly expressed in mouse placenta. In Rcho-1 cells, which recapitulate the differentiation of trophoblast giant cells of living placenta, NSBP1 expression is linked to differentiation. Disregulation of NSBP1 protein levels, by either siRNA treatment or by overexpression, alters the expression of several members of the prolactin gene family without affecting the levels of several transcription factors involved in placental differentiation. Our studies identify NSBP1 as a nucleosome binding protein that modulates the expression of prolactin gene family members most likely by inducing changes in chromatin structure.

Original languageEnglish
Pages (from-to)651-658
Number of pages8
JournalJournal of Cellular Biochemistry
Volume106
Issue number4
DOIs
Publication statusPublished - 2009 Mar 1

Keywords

  • Chromosomal proteins
  • Gene regulation
  • NSBP1
  • Placenta
  • Trophoblast

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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