The nuclear IκB family protein IκBNS influences the susceptibility to experimental autoimmune encephalomyelitis in a murine model

Shuhei Kobayashi; Akira Hara; Takayuki Isagawa; Ichiro Manabe; Kiyoshi Takeda; Takashi MaruYama

doi:10.1371/journal.pone.0110838

The nuclear IκB family protein IκB_NS influences the susceptibility to experimental autoimmune encephalomyelitis in a murine model

Shuhei Kobayashi, Akira Hara, Takayuki Isagawa, Ichiro Manabe, Kiyoshi Takeda, Takashi MaruYama

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

The nuclear IκB family protein IκB_NS is expressed in T cells and plays an important role in Interferon (IFN)-γ and Interleukin (IL)-2 production. IκB-ζ, the most similar homolog of IκB_NS, plays an important role in the generation of T helper (Th)17 cells in cooperation with RORγt, a master regulator of Th17 cells. Thus, IkB-ζ deficient mice are resistant to Th17-dependent experimental autoimmune encephalomyelitis (EAE). However, IκB-ζ deficient mice develop the autoimmune-like Sjögren syndrome with aging. Here we found that IκB_NS-deficient (Nfkbid^-/-) mice show resistance against developing Th17-dependent EAE. We found that Nfkbid^-/- T cells have decreased expression of IL-17-related genes and RORγt in response to Transforming Growth Factor (TGF)-β1 and IL-6 stimulation. Thus, IκB_NS plays a pivotal role in the generation of Th17 cells and in the control of Th17-dependent EAE.

Original language	English
Article number	e110838
Journal	PloS one
Volume	9
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0110838
Publication status	Published - 2014 Oct 27

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
General

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title = "The nuclear IκB family protein IκBNS influences the susceptibility to experimental autoimmune encephalomyelitis in a murine model",

abstract = "The nuclear IκB family protein IκBNS is expressed in T cells and plays an important role in Interferon (IFN)-γ and Interleukin (IL)-2 production. IκB-ζ, the most similar homolog of IκBNS, plays an important role in the generation of T helper (Th)17 cells in cooperation with RORγt, a master regulator of Th17 cells. Thus, IkB-ζ deficient mice are resistant to Th17-dependent experimental autoimmune encephalomyelitis (EAE). However, IκB-ζ deficient mice develop the autoimmune-like Sj{\"o}gren syndrome with aging. Here we found that IκBNS-deficient (Nfkbid-/-) mice show resistance against developing Th17-dependent EAE. We found that Nfkbid-/- T cells have decreased expression of IL-17-related genes and RORγt in response to Transforming Growth Factor (TGF)-β1 and IL-6 stimulation. Thus, IκBNS plays a pivotal role in the generation of Th17 cells and in the control of Th17-dependent EAE.",

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AU - Kobayashi, Shuhei

AU - Hara, Akira

AU - Isagawa, Takayuki

AU - Manabe, Ichiro

AU - Takeda, Kiyoshi

AU - MaruYama, Takashi

PY - 2014/10/27

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