The nuclear IκB family of proteins controls gene regulation and immune homeostasis

Takashi MaruYama

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The inhibitory IκB family of proteins is subdivided into two groups based on protein localization in the cytoplasm or in the nucleus. These proteins interact with NF-κB, a major transcription factor regulating the expression of many inflammatory cytokines, by modulating its transcriptional activity. However, nuclear IκB family proteins not only interact with NF-κB to change its transcriptional activity, but they also bind to chromatin and control gene expression. This review provides an overview of nuclear IκB family proteins and their role in immune homeostasis.

Original languageEnglish
JournalInternational Immunopharmacology
DOIs
Publication statusAccepted/In press - 2015 Feb 2

Keywords

  • Gene regulation
  • Immune homeostasis
  • NF-κB
  • Nuclear IκB family proteins
  • Transcriptional factor

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology

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