The Nrf2 transcription factor regulates basal expression of class alpha and class Mu glutathione S-transferases in the mouse, but not necessarily their induction by cancer chemopreventive agents

Michale McMaghon, Simon A. Chanas, Colin J. Henderson, C. Roland Wolf, Masayuki Yamamoto, John D. Hayes

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Nrf2 controls the basal expression of genes regulated through the antioxidant responsive element (ARF). It also contributes to the inducible expression of certain members of the ARE-gene battery. Under normal dietary conditions, the expression of class Alpha and class Mu glutathione S-transferase (GST) isoenzymes and NAD(P)H:quinone oxidoreductase (NQO) in the liver and small intestine is reduced significantly in nrf 2 (-/-) mice. Administration of chemopreventive agents to wildtype mice can result in marked induction of hepatic and intestinal GST and NQO. However, the extent of induction of these detoxication enzymes in the nrf 2 knockout mouse is variable, suggesting gene-specific effects.

Original languageEnglish
Pages (from-to)291-294
Number of pages4
JournalChemico-Biological Interactions
Volume133
Issue number1-3
Publication statusPublished - 2001 Feb 28
Externally publishedYes

Keywords

  • Cancer chemoprevention
  • Glutathione S-transferase
  • NAD(P)H: quinone oxidoreductase
  • Nrf2

ASJC Scopus subject areas

  • Toxicology

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