The Neural Circuitry that Functions as a Switch for Courtship versus Aggression in Drosophila Males

Masayuki Koganezawa, Ken ichi Kimura, Daisuke Yamamoto

    Research output: Contribution to journalArticlepeer-review

    45 Citations (Scopus)

    Abstract

    Courtship and aggression are induced in a mutually exclusive manner in male Drosophila melanogaster, which quickly chooses one of these behavioral repertoires to run depending on whether the encountered conspecific is a female or male, yet the neural mechanism underlying this decision making remains obscure. By targeted excitation and synaptic blockage in a subset of brain neurons, we demonstrate here that the fruitless (fru)-negative subfraction (∼20 cells) of a doublesex-positive neural cluster, pC1, acts as the aggression-triggering center whereas the fru-positive subfraction (∼20 cells) of pC1 acts as the courtship-triggering center, and that the mutually exclusive activation of these two centers is attained by a double-layered inhibitory switch composed of two fru single-positive clusters, LC1 and mAL. To our knowledge, this is the first report to unravel the cellular identity of the neural switch that governs the alternative activation of aggression and courtship in the animal kingdom.

    Original languageEnglish
    Pages (from-to)1395-1403
    Number of pages9
    JournalCurrent Biology
    Volume26
    Issue number11
    DOIs
    Publication statusPublished - 2016 Jan 1

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • Agricultural and Biological Sciences(all)

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