The molecular pathology of rosacea

Kenshi Yamasaki, Richard L. Gallo

Research output: Contribution to journalReview articlepeer-review

234 Citations (Scopus)


Rosacea is a common and chronic inflammatory skin disease that affects over 10 million Americans. Although the phenotypes of rosacea are clinically heterogeneous, they are all related by the presence of chronic facial skin inflammation. Until recently, the pathophysiology of this disease has been poorly understood and limited to descriptions of factors that exacerbate or improve this disorder. Recent molecular studies suggest that an altered innate immune response is involved in the pathogenesis of the vascular and inflammatory disease seen in patients with rosacea. These findings may help explain the benefits of current treatments and suggest new therapeutic strategies helpful for alleviating this disease. This article discusses the possible molecular mechanisms for the pathogenesis of rosacea from current clinical observations and laboratory research.

Original languageEnglish
Pages (from-to)77-81
Number of pages5
JournalJournal of dermatological science
Issue number2
Publication statusPublished - 2009 Aug
Externally publishedYes


  • Cathelicidin
  • Demodex
  • Immunity
  • Innate
  • Kallikrein
  • Matrix mettaloproteinase
  • Protease
  • Reactive oxygen species
  • Rosacea
  • Ultra violet light

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology


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