The molecular mechanisms of Foxp3 gene regulation

Takashi Maruyama, Joanne E. Konkel, Brian F. Zamarron, Wan Jun Chen

    Research output: Contribution to journalReview articlepeer-review

    37 Citations (Scopus)

    Abstract

    Induction of Foxp3 gene expression and acquisition of regulatory T cell fate is, understandably, a highly controlled process and one which many investigators want to illuminate. In studying the regulation of Foxp3 gene expression, several conserved non-coding regions have been identified and the role of various transcription factors at these sites has been explored. What emerges is that many factors, some positive, some negative, interact to collectively drive Foxp3 gene expression and then maintain its expression in Foxp3+ regulatory T cells. TCR signaling is imperative for Foxp3 gene expression and TGF-β is a key cytokine for initiating Foxp3 gene expression in naïve T cells. But other signaling pathways are also known to play a role in properly orchestrating Foxp3 gene expression and regulatory T cell expansion. Here we review the recent progress in understanding the complex molecular events that drive Foxp3 gene expression and allow functional regulatory T cells to develop.

    Original languageEnglish
    Pages (from-to)418-423
    Number of pages6
    JournalSeminars in Immunology
    Volume23
    Issue number6
    DOIs
    Publication statusPublished - 2011 Dec

    Keywords

    • C-Rel
    • CD4+ T cells
    • E2A
    • Foxp3
    • GATA3
    • Id3
    • TGF-β

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology

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